Each chewable tablet contains 25 mg of
phytonadione.
NOTE: Regular determinations of prothrombin
time response should be performed to guide in the initial and subsequent
administration of Vitamin K1 Chewable Tablets. The dosage should be adjusted
accordingly.
CONTRAINDICATION: Hypersensitivity to any component of this
medication.
ACTIONS: Vitamin K1 Chewable Tablets for oral
administration possess the same type and degree of activity as does
naturally occurring Vitamin K. The primary function of Vitamin K is to
stimulate the production via the liver of active prothrombin from a
precursor protein. The mechanism by which Vitamin K promotes formation of
prothrombin at the molecular level has not been established.
DESCRIPTION: Vitamin K1 Chewable Tablets
contain phytonadione with excipients in a beef-flavored tablet.
DOSAGE AND ADMINISTRATION: Dogs and Cats
Hypoprothrombinemia (with hemorrhage) - Administer
orally at the rate of 2.5-5 mg/kg of body weight (1 tablet per each 22
pounds of body weight for lower dosage or 1 tablet per each 11 pounds of
body weight for higher dosage) daily as conditions require up to 3 weeks.
Frequency and amount of oral administration should be guided by regular
determination of prothrombin time. The smallest effective dose should be
sought to minimize the risk of adverse reactions.
WARNINGS: It is recommended that Vitamin K1
Chewable Tablets be used in follow-up therapy only after administration of
Vitamin K1 Injection and hospitalization is no longer required. An immediate
coagulant effect should not be expected after administration of phytonadione
when administered orally. Phytonadione will not counteract the anticoagulant
action of heparin. Repeated large doses of Vitamin K1 are not warranted in
hepatic disease if the response to the initial therapy is unsatisfactory.
Failure to respond to Vitamin K1 may indicate that the condition being
treated is inherently unresponsive to Vitamin K1.
PRECAUTIONS: Patient may develop temporary
resistance to prothrombin-depressing anticoagulants, especially when given
larger doses of phytonadione.
CAUTION: Vitamin K1 Chewable Tablets are sold
only to licensed veterinarians.
STORAGE AND HANDLING: Protect product from
light at all times. Keep out of reach of children. Store at room
temperature.
Supplied as Vitamin K1 Chewable Tablets are
available in bottles of 50 Chewable Tablets.
FOR ANIMAL USE ONLY
KEEP OUT OF REACH OF CHILDREN
