Ventipulmin Syrup (clenbuterol hydrochloride) is
indicated for the management of horses affected with airway obstruction,
such as occurs in chronic obstructive pulmonary disease (COPD).
Clenbuterol is a beta-2-adrenergic
agonist which provides bronchodilating properties as well as other effects,
with minimum effect on the cardiovascular system. It is provided as a
colorless, palatable syrup. Ventipulmin Syrup (clenbuterol hydrochloride) is
antagonized by beta-adrenergic blocking agents.
For use in horses not intended for food.
Each ml contains: Clenbuterol HCl 72.5 mcg.
Contraindications: Ventipulmin Syrup
antagonizes the effects of prostaglandin F2 alpha and oxytocin.
Ventipulmin Syrup should not be used in pregnant mares near term. Because
tachycardia may occur, Ventipulmin Syrup should not be used in horses
suspected of having cardiovascular impairment.
Warning: The effect on reproduction in
breeding stallions and brood mares has not been determined. Treatment
starting with dosages higher than the initial dose is not recommended.
Human Warnings: This product is not for human
use or for use in animals intended for food. Keep out of the reach of
children. In case of accidental ingestion, contact a physician immediately.
Ingestion of Ventipulmin Syrup may cause undesirable reactions. Clenbuterol,
like other beta adrenergic agonists, can produce significant cardiovascular
effects in some people as evidenced by elevated pulse rate, blood pressure
changes and/or ECG changes.
Dosage and Administration:
Administer orally
twice a day (b.i.d.). Initial dose is 0.5 mL/100 lbs body weight (0.8
mcg/kg) twice daily.
Dosage Schedule:
Initial dosage: administer 0.5 mL/100 lbs (0.8
mcg/kg) for 3 days (6 treatments);
If no improvement, administer 1.0 mL/100 lbs (1.6
mcg/kg) for 3 days (6 treatments);
If no improvement, administer 1.5 mL/100 lbs (2.4
mcg/kg) for 3 days (6 treatments);
If no improvement, administer 2.0 mL/100 lbs (3.2
mcg/kg) for 3 days (6 treatments);
If no improvement, horse is non-responder to
clenbuterol and treatment should be discontinued.
Recommended duration of treatment at effective dose
is 30 days. At the end of this 30-day treatment period, drug should be
withdrawn to determine recurrence of signs. If signs return, the 30-day
treatment regimen may be repeated. If repeating treatment, the step-wise
dosage schedule should be repeated.
Dosage Calculation Chart
|
Lbs. Body Weight
|
mL/treatment at 0.5 mL/100#
(0.8 mcg/kg)
|
mL/treatment at 1.0 mL/100#
(1.6 mcg/kg)
|
mL/treatment at 1.5 mL/100#
(2.4 mcg/kg)
|
mL/treatment at 2.0 mL/100#
(3.2 mcg/kg)
|
|
500
|
2.5
|
5.0
|
7.5
|
10.0
|
|
600
|
3.0
|
6.0
|
9.0
|
12.0
|
|
700
|
3.5
|
7.0
|
10.5
|
14.0
|
|
800
|
4.0
|
8.0
|
12.0
|
16.0
|
|
900
|
4.5
|
9.0
|
13.5
|
18.0
|
|
1000
|
5.0
|
10.0
|
15.0
|
20.0
|
|
1100
|
5.5
|
11.0
|
16.5
|
22.0
|
|
1200
|
6.0
|
12.0
|
18.0
|
24.0
|
|
1300
|
6.5
|
13.0
|
19.5
|
26.0
|
|
1400
|
7.0
|
14.0
|
21.0
|
28.0
|
|
1500
|
7.5
|
15.0
|
22.5
|
30.0
|
|
1600
|
8.0
|
16.0
|
24.0
|
32.0
|
|
1700
|
8.5
|
17.0
|
25.5
|
34.0
|
|
1800
|
9.0
|
18.0
|
27.0
|
36.0
|
Administer two treatments per day.
Directions for Administration: Remove safety
cap and seal; replace with enclosed plastic dispensing cap. Remove cover
from dispensing tip and connect syringe (without needle). Draw out
appropriate volume of Ventipulmin Syrup. Administer orally to the horse.
Replace cover on dispensing tip to prevent leakage.
Precaution: The safety cap should be placed
on the bottle when not in use.
Adverse Reactions: Mild sweating, muscle
tremor, restlessness, urticaria and tachycardia may be observed in some
horses during the first few days of treatment. May cause elevated creatine
kinase (CK) serum levels. Ataxia was observed in 3 out of 239 horses (1.3%)
in clinical studies.
How Supplied: Ventipulmin Syrup is available
in 50 mL, 100 mL, 330 mL, and 460 mL plastic bottles containing 72.5 mcg
clenbuterol HCl per mL.
Storage: Store at controlled room temperature
(59-86°F) (15-30°C). Avoid freezing.
