Temaril-P Tablets
Antipruritic-Antitussive-Anti-inflammatory
Temaril-P (trimeprazine with prednisolone) is a unique formula that combines three therapeutic effects - antipruritic, antitussive and anti-inflammatory - to relieve the itch caused by allergic, inflammatory and parasitic dermatosis.
1. Antipruritic: TEMARIL-P is recommended for the relief of itching regardless
of cause. Its usefulness has been demonstrated for the relief of itching and the
reduction of inflammation commonly associated with most skin disorders of dogs
such as the eczema caused by internal disorders, otitis, and dermatitis
(allergic, parasitic, pustular, and nonspecific). It often relieves pruritus
which does not respond to other therapy. With any pruritus treatment, the cause
should be determined and corrected; otherwise, signs are likely to recur
following discontinuance of therapy.
2. Antitussive: TEMARIL-P has been found to be effective therapy and
adjunctive therapy in various cough conditions of dogs. Therefore, in addition
to its Antipruritic action, TEMARIL-P is recommended for the treatment of
"kennel cough" or tracheobronchitis, bronchitis including all allergic
bronchitis and infections and coughs of nonspecific origin. (Coughs due to
cardiac insufficiencies would not be expected to respond to TEMARIL-P
therapy.) As with any Antitussive treatment, the etiology of the cough should be
determined and eliminated if possible. Otherwise, symptoms are likely to recur
following discontinuance of therapy.
Pharmacology:
Action: The exclusive TEMARIL-P
formula combines the Antipruritic and Antitussive action of trimeprazine with
the anti-inflammatory action of prednisolone. A therapeutic effect is attained
by administering the tablets twice daily.
Note: TEMARIL-P may be administered to animals suffering from acute or chronic
bacterial infections provided the infection is controlled by appropriate
antibiotic or chemotherapeutic agents.
Dosage and Administration:
Recommended Dosage: The same
dosage schedule may be followed for both Antipruritic and Antitussive therapy.
Initial dosage by weight:
- Up to 10 lbs . . . 1/2 tablet twice daily
- 11-20 lbs . . . 1 tablet twice daily
- 21-40 lbs . . . 2 tablets twice daily
- Over 40 lbs . . . 3 tablets twice daily
After 4 days, reduce dosage to 1/2 of the initial
dose or to an amount just sufficient to maintain remission of symptoms.
Individual animal response will vary and dosage should be adjusted until proper
response is obtained.
Active Ingredients:
Composition: Each tablet contains
trimeprazine tartrate (USP) 10-[3-(Dimethylamino)-2-methylpropyl] phenothiazine
tartrate (2:1) equivalent to trimeprazine, 5 mg, and prednisolone, 2 mg.
Precautions:
Store in a dry, cool place at
temperatures not above 25°C (77°F).
Cautions:
Federal law restricts this drug to use
by or on the order of a licensed veterinarian.
All the cautions applicable to cortisone and to phenothiazine derivatives apply
also to TEMARIL-P.
Prolonged treatment with TEMARIL-P must be withdrawn gradually. Use of
corticosteroids, depending on dose, duration, and specific steroid, may result
in inhibition of endogenous steroid production following drug withdrawal. In
patients presently receiving or recently withdrawn from systemic steroid
treatments, therapy with a rapidly acting corticosteroid should be considered in
unusually stressful situations.
Warnings:
Clinical and experimental data
have demonstrated that corticosteroids administered orally or by injection to
animals may induce the first stage of parturition if used during the last
trimester of pregnancy and may precipitate premature parturition followed by
dystocia, fetal death, retained placenta, and metritis. Additionally,
corticosteroids administered to dogs, rabbits, and rodents during pregnancy have
resulted in cleft palate in offspring. Corticosteroids administered to dogs
during pregnancy have also resulted in other congenital anomalies, including
deformed forelegs, phocomelia, and anasarca. If a vasoconstrictor is needed,
norepinephrine should be used in lieu of epinephrine. Phenothiazine derivatives
may reverse the usual elevating action of epinephrine causing further lowering
of blood pressure.
Side Effects:
Possible side effects attributable
to corticosteroids include sodium retention and potassium loss, negative
nitrogen balance, suppressed adrenal cortical function, delayed wound healing,
osteoporosis, elevated levels of SGPT and SAP, and vomiting and diarrhea
(occasionally bloody). Cushing's syndrome in dogs has been reported in
association with prolonged or repeated steroid therapy. Possible increased
susceptibility to bacterial invasion and/or the exacerbation of preexisting
bacterial infection may occur in patients receiving corticosteroids. As noted
above, however, this problem can be avoided by concomitant use of appropriate
anti-infective agents. Possible side effects attributable to phenothiazine
derivatives include sedation; protruding nictitating membrane; blood dyscrasias;
intensification and prolongation of the action of analgesics, sedatives and
general anesthetics; and potentiation of organophosphate toxicity and the
activity of procaine hydrochloride.
It should be remembered that the premonitory signs of cortisone over-dosage,
such as sodium retention and edema, may not occur with prednisolone. Therefore,
the veterinarians must be alert to detect less obvious side effects, such as
blood dyscrasias, polydipsia and polyuria.
The appearance and severity of side effects are dose related and are minimal at
the recommended dosage level. If troublesome side effects are encountered, the
dosage of TEMARIL-P should be reduced and discontinued unless the severity of
the condition being treated makes its relief paramount.
How Supplied: 100 tablet bottle
Pfizer Animal Health
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.
