Broad Spectrum Parasiticide For Heartworms, Fleas & Intestinal Worms

Novartis Sentinel Chewables are palatable once-a-month tablets for the prevention of heartworm disease in dogs and puppies. Sentinel Spectrum also prevents and controls flea populations as well as treats and controls tapeworms, whipworms, roundworms and hookworms.

Sentinel Spectrum Chewables are indicated for use in dogs and puppies, six weeks of age and older, and two pounds body weight or greater. Sentinel Spectrum are indicated for the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations; the treatment and control of adult hookworm ( Ancylostoma caninum), adult roundworms (Toxocara canis, Toxascaris leonina), adult tapeworm (Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections. and adult whipworm (Trichuris vulpis) infections.

Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.

Sentinel Spectrum may be used concurrently with CAPSTAR (nitenpyram) Tablets to provide a Flea Management System that kills adult fleas and prevents flea eggs from hatching. Please see the Supplemental Package Insert provided with this product for information about concurrent use of the two products.

Without concurrent use of an adulticide, adequate flea control may not be achieved in dogs that have repeated exposure to flea infected animals or environments.

Precautions:

Do not use in puppies less than six weeks of age and less than two pounds of body weight. Prior to administration of Sentinel Spectrum, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with Sentinel Spectrum. Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Sentinel Spectrum Chewables immediately break the flea life cycle by inhibiting egg development. However, pre-existing flea populations may continue to develop and emerge after treatment with Sentinel Spectrum tablets has begun. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. Therefore, noticeable control may not be observed until several weeks after dosing when a pre-existing infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. The concurrent use of an approved adulticide, like CAPSTAR may be employed depending on the severity of the infestation.

If a Sentinel Spectrum-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. These adult fleas are unable to produce viable offspring. The temporary use of an adulticide product may be necessary to kill these adult fleas.

Dosage:

Sentinel Spectrum Tablets are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg) lufenuron, and 2.28 mg/lb (5 mg/kg) praziquantel.

Body Weight / Sentinel Size

• 2 to 8 lbs . . . 2.3 mg
• 8.1 to 25 lbs . . . 5.75 mg
• 25.1 to 50 lbs . . . 11.5 mg
• 50.1 to 100 lbs . . . 23.0 mg
• Dogs over 100 lbs . . . give the appropriate combination of tablets

Administration:
TO ENSURE ADEQUATE ABSORPTION, ALWAYS ADMINISTER SENTINEL SPECTRUM TO DOGS IMMEDIATELY AFTER OR IN CONJUNCTION WITH A NORMAL MEAL.

Sentinel Spectrum Chewables are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets. Administer Sentinel Spectrum to dogs, immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible.

Sentinel Spectrum must be administered monthly, preferably on the same date each month. Treatment with Sentinel Spectrum may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until at least 6 months after the dog's last seasonal exposure. In areas with year-round infestations, treatment should continue through the entire year without interruption.

If a dose is missed and a 30-day interval between dosing is exceeded, administer Sentinel Spectrum immediately and resume the monthly dosing schedule.

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian

Adverse Reactions:

The following adverse reactions have been reported in dogs after giving milbemycin oxime or lufenuron: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation and weakness.

How Supplied: Sentinel Spectrum Chewable Tablets are available in four tablet sizes formulated according to the weight of the dog. Each tablet size is available in color-coded packages of six tablets each, which are packaged 10 per display carton.

Storage Conditions:

Store in a dry place at controlled room temperature, between 59° and 86°F (15-30°C).

Novartis Animal Health

Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.