Revolt (Selamectin) Heartworm Preventive
Topical Parasiticide For Dogs & Cats
Revolt Heartworm Preventive by Aurora Pharmaceutical is a once-a-month topical treatment for heartworms and parasite protection. In Cats, Revolt protects against heartworms, roundworms, hookworms, fleas and ear mites. In Dogs, Revolt protects against heartworms, fleas, ticks, ear mites and sarcoptic mange. Recommended for use in dogs 6 weeks of
age or older and cats 8 weeks of age and older. Revolt (selamectin) is comparable to Revolution (selamectin).
Dogs:
Revolt kills adult fleas and prevents flea eggs from
hatching for one month and is indicated for the prevention and control of flea
infestations
(Ctenocephalides felis), prevention of heartworm disease
caused by
Dirofilaria immitis, and the treatment and control of ear
mite
(Otodectes cynotis) infestations. Revolt also is indicated for
the treatment and control of sarcoptic mange
(Sarcoptes scabiei) and
for the control of tick infestations due to
(Dermacentor variabilis).
- Use in dogs 6 weeks of age or older against the following parasites:
adult fleas, flea eggs, heartworm, ear mites, sarcoptic mites, and
American dog tick
- Killing adult fleas and preventing flea eggs from hatching for one
month, and indicated for prevention and control of flea infestations (
Ctenocephalides
felis
)
- Prevention of heartworm disease caused by Dirofilaria immitis
- Treatment and control of ear mite (Otodectes cynotis)
infestations
- Treatment and control of sarcoptic mange (Sarcoptes scabiei)
- Control of tick (Dermacentor variabilis) infestations
Cats:
Revolt kills adult fleas and prevents flea eggs from
hatching for one month and is indicated for the prevention and control of flea
infestations
(Ctenocephalides felis), prevention of heartworm disease
caused by
Dirofilaria immitis, and the treatment and control of ear
mite
(Otodectes cynotis) infestations. Revolt is also indicated for
the treatment and control of roundworm
(Toxocara cati) and intestinal
hookworm
(Ancylostoma tubaeforme) infections in cats.
- Kills adult fleas (Ctenocephalides felis) and prevents flea eggs from
hatching
- Prevents heartworm disease caused by Dirofilaria immitis
- Treats and controls ear mites (Otodectes cynotis)
- Treats and controls roundworms (Toxocara cati) and hookworms (Ancylostoma
tubaeforme)
Description:
Revolt (selamectin) Topical Parasiticide is
available as a colorless to yellow, ready to use solution in single dose tubes
for topical (dermal) treatment of dogs six weeks of age and older and cats eight
weeks of age and older. The content of each tube is formulated to provide a
minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin.
Do not use in sick, debilitated or underweight
animals.
Precautions:
Prior to administration of Revolt, dogs should be
tested for existing heartworm infections. At the discretion of the veterinarian,
infected dogs should be treated to remove adult heartworms.
Revolt is not
effective against adult
D. immitis and, while the number of circulating
microfilariae may decrease following treatment,
Revolt is not effective for
microfilariae clearance.
Hypersensitivity reactions have not been observed in
dogs with patent heartworm infections administered three times the recommended
dose of
Revolt. Higher doses were not tested.
Adverse Reactions:
Transient localized
alopecia with or without inflammation at or near the site of application is is observed in approximately <1% of cases. Other signs observed rarely include vomiting, loose stool or diarrhea
with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle
tremors.
Dosage:
The recommended minimum dose is 2.7 mg selamectin per
pound (6 mg/kg) of body weight.
Administer the entire contents of a single dose tube (or
two tubes used in combination for dogs weighing over 130 pounds) of
Revolt topically in accordance with the following tables. (see ADMINISTRATION for the
recommended treatment intervals).
|
Cats (lb)
|
Package color
|
mg per tube
|
Potency
(mg/mL)
|
Administered volume (mL)
|
|
Up to 5
|
Mauve
|
15 mg
|
60
|
0.25
|
|
5.1-15
|
Blue
|
45 mg
|
60
|
0.75
|
For cats over 15 lbs use the appropriate combination of
tubes.
|
Dogs (lb)
|
Package color
|
mg per tube
|
Potency
(mg/mL)
|
Administered volume (mL)
|
|
Up to 5
|
Mauve
|
15 mg
|
60
|
0.25
|
|
5.1-10
|
Purple
|
30 mg
|
120
|
0.25
|
|
10.1-20
|
Brown
|
60 mg
|
120
|
0.5
|
|
20.1-40
|
Red
|
120 mg
|
120
|
1.0
|
|
40.1-85
|
Teal
|
240 mg
|
120
|
2.0
|
|
85.1-130
|
Plum
|
360 mg
|
120
|
3.0
|
For dogs over 130 lbs use the appropriate combination of
tubes.
Recommended for use in dogs 6 weeks of age and older and
in cats 8 weeks of age and older.
Administration:
A veterinarian or veterinary technician should
demonstrate or instruct the pet owner regarding the appropriate technique for
applying
Revolt topically to dogs and cats prior to first use.
Firmly press the cap down to puncture the seal on the Revolt tube; a clicking sound will confirm that the cap has successfully
punctured the seal. Remove the cap and check to ensure that the tip of the tube
is open. To administer the product, part the hair on the back of the animal at
the base of the neck in front of the shoulder blades until the skin is visible.
Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty
its entire contents directly onto the skin in one spot. Keeping the tube
squeezed, drag it away from the liquid and lift to remove. Check the tube to
ensure that it is empty. Do not massage the product into the skin. Due to
alcohol content, do not apply to broken skin. Avoid contact between the product
and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the
animal 2 or more hours after treatment will not reduce the effectiveness of
Revolt. Stiff hair, clumping of hair, hair discoloration, or a slight
powdery residue may be observed at the treatment site in some animals. These
effects are temporary and do not affect the safety or effectiveness of the
product. Discard empty tubes in your ordinary household refuse.
Flea Control in Dogs and Cats
For the prevention and control of flea infestations, Revolt should be administered at monthly intervals throughout the flea
season, starting one month before fleas become active. In controlled laboratory
studies >98% of fleas were killed within 36 hours. Results of clinical field
studies using
Revolt monthly demonstrated >90% control of flea infestations
within 30 days of the first dose. Dogs and cats treated with
Revolt,
including those with pre-existing flea allergy dermatitis, showed improvement in
clinical signs associated with fleas as a direct result of eliminating the fleas
from the animals and their environment.
If the dog or cat is already infested with fleas when
the first dose of
Revolt is administered, adult fleas on the animal are
killed and no viable fleas hatch from eggs after the first administration.
However, an environmental infestation of fleas may persist for a short time
after beginning treatment with
Revolt because of the emergence of adult
fleas from pupae.
Heartworm Prevention in Dogs and Cats
For the prevention of heartworm disease, Revolt must
be administered on a monthly basis.
Revolt may be administered year-round or
at least within one month after the animal's first exposure to mosquitoes and
monthly thereafter until the end of the mosquito season. The final dose must be
given within one month after the last exposure to mosquitoes. If a dose is
missed and a monthly interval between dosing is exceeded then immediate
administration of
Revolt and resumption of monthly dosing will minimize the
opportunity for the development of adult heartworms. When replacing another
heartworm preventive product in a heartworm disease prevention program, the
first dose of
Revolt must be given within a month of the last dose of the
former medication.
Selamectin, the active ingredient in Revolt, is a
macrocyclic lactone compound. These compounds effectively prevent the
development of adult heartworms when administered to dogs and cats within one
month of exposure to infective (L
3) Dirofilaria immitis
larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however,
if first administered >2 months after exposure to infective larvae. Thus, in
heartworm endemic regions, delaying initiation of heartworm prevention using
Revolt beyond 2 months of first exposure to infective larvae (e.g., starting
puppies and kittens at >8 weeks of age), or gaps of >2 months in the
administration of
Revolt during periods of heartworm transmission, increases
the risk of the animal acquiring heartworms. Animals with unknown heartworm
history that test negative for heartworms prior to the initiation of
Revolt may be harboring pre-patent infections at the time Revolt was started.
Testing such animals 3-4 months after initiation of Revolt would be
necessary to confirm their negative heartworm status.
At the discretion of the veterinarian, cats ?6 months of
age may be tested to determine the presence of existing heartworm infections
before beginning treatment with
Revolt. Cats already infected with adult
heartworms can be given
Revolt monthly to prevent further infections.
Ear Mite Treatment in Dogs and Cats
For the treatment of ear mite (O. cynotis)
infestations in dogs and cats,
Revolt should be administered once as a
single topical dose. A second monthly dose may be required in some dogs. Monthly
use of
Revolt will control any subsequent ear mite infestations. In the
clinical field trials ears were not cleaned, and many animals still had debris
in their ears after the second dose. Cleansing of the infested ears is
recommended to remove the debris.
Sarcoptic Mange Treatment in Dogs
For the treatment of sarcoptic mange (S. scabiei)
in dogs,
Revolt should be administered once as a single topical dose. A
second monthly dose may be required in some dogs. Monthly use of
Revolt will
control any subsequent sarcoptic mange mite infestations. Because of the
difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness
assessments also were based on resolution of clinical signs. Resolution of the
pruritus associated with the mite infestations was observed in approximately 50%
of the dogs 30 days after the first treatment and in approximately 90% of the
dogs 30 days after the second monthly treatment.
Tick Control in Dogs
For the control of tick (Dermacentor variabilis)
infestations in dogs,
Revolt should be administered on a monthly basis. In
heavy tick infestations, complete efficacy may not be achieved after the first
dose. In these cases, one additional dose may be administered two weeks after
the previous dose, with monthly dosing continued thereafter.
Nematode Treatment in Cats
For the treatment of intestinal hookworm (A.
tubaeforme)
and roundworm (T. cati) infections, Revolt should
be applied once as a single topical dose.
WARNINGS: Not for human use. Keep out of the
reach of children.
US Federal law restricts this drug to
use by or on the order of a licensed veterinarian
Storage: Store below 30°C (86°F).
Flammable - Keep away from heat, sparks, open flames or
other sources of ignition.
HOW SUPPLIED: Available in seven separate dose
strengths for dogs and cats of different weights (see Dosage).
Revolt for
puppies and kittens is available in cartons containing 3 single dose tubes.
Revolt for cats and dogs is available in cartons containing 3 or 6 single
dose tubes.
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.
