Quest Gel Horse Dewormer & Boticide

(Moxidectin)

QUEST (moxidectin) 2% Equine Oral Gel is a parasiticide, dewormer and boticide. When administered at the recommended dose level of 0.4 mg moxidectin/kg (2.2 lb) body weight is effective in the treatment and control of the following stages of gastrointestinal parasites in horses and ponies:

Large strongyles: Strongylus vulgaris - (adults and L₄/L₅ arterial stages); Strongylus edentatus - (adults and tissue stages); Triodontophorus brevicauda - (adults); Triodontophorus serratus - (adults).

Small strongyles: Cyathostomum spp. - (adults); Cylicocyclus spp. - (adults); Cylicostephanus spp. - (adults); Gyalocephalus capitatus - (adults); Undifferentiated lumenal larvae.
Encysted cyathostomes: Late L₃ and L₄ mucosal cyathostome larvae.

Ascarids: Parascaris equorum - (adults and L₄ larval stages).

Pin worms: Oxyuris equi - (adults and L₄ larval stages).

Hair worms: Trichostrongylus axei - (adults).

Large-mouth stomach worms: Habronema muscae - (adults).

Horse stomach bots: Gasterophilus intestinalis - (2nd and 3rd instars); Gasterophilus nasalis - (3rd instars).

One administration of the recommended dose rate of QUEST 2% Equine Oral Gel also suppresses strongyle egg production through 84 days. QUEST is indicated for use in horses and ponies, including breeding mares and stallions, and foals four months of age and older.

Mode of Action: QUEST 2% Equine Oral Gel acts by interfering with chloride channel-mediated neurotransmission in the parasite. This results in paralysis and elimination of the parasite. Moxidectin is safe for use in horses and ponies because it does not have the same injurious effect on the mammalian nervous system.

Dosage and Administration: QUEST (moxidectin) 2% Equine Oral Gel is specially formulated as a palatable gel which is easily administered to horses and ponies.

QUEST Gel is packaged in ready-to-use Sure-Dial syringes. The syringe is calibrated in 50-pound increments, up to 1150 pounds. This enables the administration of the recommended dose level of 0.4 mg moxidectin/kg body weight by choosing a setting consistent with the animal's weight.

How to set the dose: Since the dose is based on the weight of the animal, you need to use a scale or weight tape to find each animal's weight before treating with QUEST Gel. Once the weight is known, set the dose for each horse or pony as follows.
1. Hold the syringe with the capped end pointing to the left and so that you can see the weight measurements and tick marks (small black lines). Each tick mark relates to 50 lbs. of body weight.
2. Turn the green dial ring until the left side of the ring lines up with the weight of the animal.
How to give QUEST Gel to a horse or pony:
1. Make sure there is no feed in the animal's mouth.
2. Remove the cap from the end of the syringe. Save the cap for reuse.
3. Place the tip of the syringe inside the animal's mouth at the space between the teeth.
4. Gently push the plunger until it stops, depositing the gel on the back of the tongue.
5. Remove the syringe from the animal's mouth and raise the animal's head slightly to make sure it swallows the gel.
6. Replace the syringe cap.

Treating a second horse or pony with the same syringe: If the first animal you treat weighs less than 1150 lbs., there will be gel left in the syringe. You can use this gel to treat other horses or ponies. To set the next dose, add the weight of the animal you want to treat to the dose setting already on the syringe. For example, if the syringe was first used to treat a 250 lb. animal, the green dial ring is set on 250 lbs. To treat a 500 lb. animal next, move the green dial ring to the 750 lb. marking (250+500=750). You need more than one syringe to treat horses weighing more than 1150 lbs.

Each syringe of QUEST 2% Equine Oral Gel may be used to treat more than one animal especially when dosing foals, ponies and growing and lighter breeds of horses. The table below will help estimate the number of horses or ponies the contents of each syringe will treat.

Age	Ponies			Light Horses			Heavy Horses
	Weight		Treated Animals	Weight		Treated Animals	Weight		Treated Animals
	(lbs)	(kg)	(per syringe)	(lbs)	(kg)	(per syringe)	(lbs)	(kg)	(per syringe)
4 months	150	(68)	7	250	(113)	4	350	(159)	3
8 months	200	(91)	5	350	(159)	3	550	(249)	2
Mature	450	(204)	2	850	(386)	1	1100+	(499+)	1

Active Ingredients: Contains 20 mg moxidectin/mL (2.0% w/v).

Animal Safety: QUEST (moxidectin) 2% Equine Oral Gel can be safely administered at the recommended dose of 0.4 mg moxidectin/kg body weight to horses and ponies of all breeds at least 4 months of age or older. Transient depression, ataxia and recumbency may be seen when very young or debilitated animals are treated. In these instances, supportive care may be advisable. Reproductive safety studies demonstrate a wide margin of safety when the product is used in the treatment of estrual and pregnant mares and breeding stallions.

Discussion: Strategic Protection Programs: Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. For best control of parasites, all horses and ponies should be included in a strategic treatment program, with particular attention given to high performance animals, brood mares, stallions and foals. In foals, initial treatment is recommended at 4 months of age, after which they should be included in a recurrent treatment program. Because QUEST provides effective control of the mucosal stages of small strongyles (encysted cyathostomes), it is useful in reducing the frequency of treatment required for successful strategic equine parasite control. A veterinarian can assist in preparing the best program for your needs.
QUEST 2% Equine Oral Gel when used at the recommended dose rate suppresses strongyle egg production through 84 days following a single oral administration. This residual strongyle control reduces pasture contamination and provides a period of protection from reinfection for horses and ponies maintained on the same pasture.

Presentation:
QUEST 2% Equine Oral Gel is available in one syringe applicator size. Each Sure-Dial syringe contains 0.4 oz (11.3 g) of QUEST 2% Equine Oral Gel which is sufficient to treat a single horse weighing up to 1150 lb, or two or more lighter animals with a combined body weight of up to 1150 lb.

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