PANACUR EQUINE DEWORMER 10%
25g, Paste
Fenbendazole
InterVet Panacur (fenbendazole) Paste 10% is indicated for the control of large
strongyles (Strongylus edentatus, S. equinus, S. vulgaris), encysted
early third stage (hypobiotic), late third stage and fourth stage cyathostome
larvae, small strongyles, pinworms (Oxyuris equi), ascarids (Parascaris
equorum), and arteritis caused by fourth stage larvae of Strongylus
vulgaris in horses.
Panacur (fenbendazole) Paste
10% is approved for use concomitantly with an approved form of trichlorfon.
Thichlorfon is approved for the treatment of stomach bots (Gasterophilus
spp.) in horses. Refer to the manufacturer's label for directions for use and
cautions for trichlorfon.
Panacur Paste 10%
contains the active anthelmintic, fenbendazole. The chemical name of
fenbendazole is methyl 5-(phenylthio)-2-benzimidazole carbamate.
Each gram of Panacur (fenbendazole)
Paste 10% contains 100 mg of fenbendazole and is flavored with artificial
apple-cinnamon liquid.
ACTIONS:
The antiparasitic action of Panacur (fenbendazole) Paste 10% is believed to be
due to the inhibition of energy metabolism in the parasite.
CONTRAINDICATIONS: There are no
known contraindications for the use of Panacur (fenbendazole) Paste 10% in
horses.
PRECAUTIONS:
Side effects associated with Panacur (fenbendazole) Paste 10% could not be
established in well-controlled safety studies in horses with single doses as
high as 454 mg/lb (1000 mg/kg) and 15 consecutive daily doses of 22.7 mg/lb (50
mg/kg). Particularly with higher doses, the lethal action of fenbendazole may
cause the release of antigens by the dying parasites. This phenomenon may result
in either a local or systemic hypersensitive reaction. As with any drug, these
reactions should be treated symptomatically.
Panacur (fenbendazole) Paste
10% has been evaluated for safety in pregnant mares during all stages of
gestation with doses as high as 11.4 mg/lb (25 mg/kg) and in stallions with
doses as high as 11.4 mg/lb (25 mg/kg). No adverse effects on reproductivity
were detected. The recommended dose for control of fourth stage larvae of
Strongylus vulgaris, 4.6 mg/lb (10 mg/kg) daily for 5 consecutive days, has
not been evaluated for safety in stallions or pregnant mares.
Internal
Parasites: Regular deworming at
intervals of six to eight weeks may be required due to the possibility of
reinfection.
Migrating Tissue
Parasites: In the case of
fourth stage larvae of Strongylus vulgaris, treatment and retreatment
should be based on the life cycle and epidemiology. Treatment should be
initiated in the spring and repeated in the fall after a six-month interval.
Optimum Deworming Program for
Control of S. vulgaris: Optimum reduction of S. vulgaris
infections is achieved by reducing the infectivity of the pastures. When horses
are running on pastures, in temperate North America, maximum pasture infectivity
occurs in October-December. If horses are removed from those pastures in
January, pasture infectivity will decline to zero by July 1. Egg production of
S. vulgaris is minimal from January through April, peaking in August and
declining to minimal values in December.
Recommended
Deworming Program:** December
1, February 1, April 1, June 1, August 1, October 1.
The two treatments that are in
bold type are the recommended periods when the 5-day treatment regimen for the
control of the migrating larvae of S. vulgaris should be performed.
** For other areas in the
world, retreatment periods for the migrating larvae of S. vulgaris may be
different; consult with your veterinarian.
CAUTIONS:
Keep this and all medications out of the reach of children.
When using Panacur (fenbendazole)
Paste 10% concomitantly with trichlorfon, refer to the manufacturer's labels for
use and cautions for trichlorfon.
WARNING:
Do not use in horses intended for food.
DOSAGE:
Horse:
Panacur (fenbendazole) Paste 10% is administered orally at a rate of 2.3 mg/lb
(5 mg/kg) for the control of large strongyles, small strongyles, and pinworms.
One syringe will deworm a 2,500 lb horse. For foals and weanlings (less than 18
months of age) where ascarids are a common problem, the recommended dose is 4.6
mg/lb (10 mg/kg); one syringe will deworm a 1250 lb horse. For control of
encysted early third stage (hypobiotic), late third stage and fourth stage
cyathostome larvae, and fourth stage larvae of Strongylus vulgaris, the
recommended dose is 4.6 mg/lb (10 mg/kg) for 5 consecutive days; administer one
syringe for each 1250 lbs of body weight per day.
SEE PRECAUTIONS FOR RETREATMENT
RECOMMENDATIONS.
DIRECTIONS FOR
USE:
1. Determine the weight of the
horse.
2. Remove syringe tip.
3. Turn the dial ring until the
edge of the ring nearest the tip lines up with zero.
4. Depress plunger to advance
paste to tip.
5. Now set the dial ring at the
graduation nearest the weight of the horse (do not underdose).
6. Horse's mouth must be free
of food.
7. Insert nozzle of syringe
through the interdental space and deposit the paste on the back of the tongue by
depressing the plunger.
Store at or below 25°C
(75°F)
CONSULT YOUR VETERINARIAN FOR
ASSISTANCE IN THE DIAGNOSIS, TREATMENT AND CONTROL OF PARASITISM.
