Anti-inflammatory-Antipruritic-Antifungal-Antibacterial
EnteDerm Ointment is particularly useful in the treatment of acute and chronic otitis of varied etiologies, in interdigital cysts in cats and dogs and in anal gland infections in dogs.
EnteDerm is also indicated in the management of dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly those caused, complicated, or threatened by bacterial or candidal (Candida albicans) infections. It is also of value in eczematous dermatitis, contact dermatitis, and seborrheic dermatitis; and as an adjunct in the treatment of dermatitis due to parasitic infestation.
EnteDerm Ointment (generic of Panolog) combines
nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide in a
non-irritating, soothing mineral oil base.
Active Ingredients per ml:
- Nystatin . . . 100,000 units
- Neomycin sulfate . . . 2.5 mg
- Thiostrepton . . . 2,500 units
- Triamcinolone acetonide . . . 1 mg
The preparation is intended
for local therapy in a variety of cutaneous disorders of dogs and cats; it
is especially useful in disorders caused, complicated, or threatened by
bacterial and/or candidal (monilial) infection.
ACTIONS:
By virtue of its four active
ingredients, EnteDerm Ointment provides four basic therapeutic effects:
anti-inflammatory, antipruritic, antifungal and antibacterial. Triamcinolone
acetonide is a potent synthetic corticosteroid providing rapid and prolonged
symptomatic relief on topical administration. Inflammation, edema, and
pruritis promptly subside, and lesions are permitted to heal. Nystatin is
the first well-tolerated antifungal antibiotic of dependable efficacy for
the treatment of cutaneous infections caused by Candida
albicans (Monilia). Nystatin is fungistatic in
vitro against a variety of yeast and yeast-like fungi including many
fungi pathogenic to animals. No appreciable activity is exhibited against
bacteria. Thiostrepton has a high order of activity against gram-positive
organisms, including many which are resistant to other antibiotics; neomycin
exerts antimicrobial action against a wide range of gram-positive and
gram-negative bacteria. Together they provide comprehensive therapy against
those organisms responsible for most superficial bacterial infections.
WARNINGS:
Clinical and experimental data
have demonstrated that corticosteroids administered orally or by injection
to animals may induce the first stage of parturition if used during the last
trimester of pregnancy and may precipitate premature parturition followed by
dystocia, fetal death, retained placenta, and metritis.
Additionally, corticosteroids
administered to dogs, rabbits and rodents during pregnancy have resulted in
cleft palate in the offspring. In dogs, other congenital anomalies have
resulted: deformed forelegs, phocomelia, and anasarca.
Keep out of
reach of children. If swallowed, get medical help or contact a Poison
Control Center right away.
PRECAUTIONS:
EnteDerm Ointment is not
intended for the treatment of deep abscesses or deep-seated infections such
as inflammation of the lymphatic vessels. Parenteral antibiotic therapy is
indicated in these infections.
EnteDerm Ointment (Nystatin-Neomycin
Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment) has been extremely
well tolerated. Cutaneous reactions attributable to its use have been
extremely rare. The occurrence of systemic reactions is rarely a problem
with topical administration. There is some evidence that corticosteroids can
be absorbed after topical application and cause systemic effects. Therefore,
an animal receiving EnteDerm Ointment therapy should be observed closely for
signs such as polydipsia, polyuria, and increased weight gain.
EnteDerm Ointment is not
generally recommended for the treatment of deep or puncture wounds or
serious burns.
Sensitivity to neomycin may
occur. If redness, irritation, or swelling persists or increases,
discontinue use. Do not use if pus is present since the drug may allow the
infection to spread. Avoid ingestion. Oral or parenteral use of
corticosteroids (depending on dose, duration of use, and specific steroid)
may result in inhibition of endogenous steroid production following drug
withdrawal.
SIDE EFFECTS:
SAP and SGPT (ALT) enzyme
elevations, polydipsia and polyuria, vomiting, and diarrhea (occasionally
bloody) have been observed following parenteral or systemic use of synthetic
corticosteroids in dogs.
Cushing's syndrome has been
reported in association with prolonged or repeated steroid therapy in dogs.
Temporary hearing loss has
been reported in conjunction with treatment of otitis with products
containing corticosteroids. However, regression usually occurred following
withdrawal of the drug. If hearing dysfunction is noted during the course of
treatment with EnteDerm Ointment, discontinue its use.
CAUTION:
Before instilling any
medication into the ear, examine the external ear canal thoroughly to be
certain the tympanic membrane is not ruptured in order to avoid the
possibility of transmitting infection to the middle ear as well as damaging
the cochlea or vestibular apparatus from prolonged contact. If hearing or
vestibular dysfunction is noted during the course of treatment, discontinue
the use of EnteDerm Ointment.
DOSAGE AND
ADMINISTRATION:
Frequency of administration is
dependent on the severity of the condition. For mild inflammations,
application may range from once daily to once a week; for severe conditions EnteDerm Ointment may be applied as often as two to three times daily, if
necessary. Frequency of treatment may be decreased as improvement occurs.
Wear gloves during the
administration of the ointment or wash hands immediately after application.
Otitis:
Clean ear canal of impacted cerumen. Inspect canal and remove any
foreign bodies such as grass awns, ticks, etc. Instill three to five drops
of EnteDerm Ointment.
Preliminary use of a local
anesthetic may be advisable.
Infected
Anal Glands, Cystic Areas, etc.: Drain gland or cyst and then fill with EnteDerm Ointment.
Other
Dermatologic Disorders: Clean affected areas, removing any encrusted
discharge or exudate. Apply EnteDerm Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone
Acetonide Ointment) sparingly in a thin film.
Federal law restricts this drug to use by or on the order of a licensed veterinarian
Store at room temperature; avoid excessive heat (104°F). Do not
store above 86°F
VetOne
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