Comfortis Chewable Tablets

COMFORTIS chewable tablets are given orally once a month, at the recommended minimum dosage:

• Dogs: 13.5 mg/lb (30 mg/kg)
• Cats: 22.5 mg/lb (50 mg/kg)
  

Recommended Monthly Dosage Schedule:

• Cats
  • 2 to 4 lbs . . . 90 mg (yellow box - one tablet)
    
  • 4.1 to 6 lbs . . . 140 mg (pink box - one tablet)
    
  • 6.1 to 12 lbs . . . 270 mg (orange box - one tablet)
    
  • 12.1 to 24 lbs . . . 560 mg (green box - one tablet)
    
    
• Dogs
  • 3.3 to 4.9 lbs . . . 90 mg (yellow box - one tablet)
    
  • 5 to 10 lbs . . . 140 mg (pink box - one tablet)
    
  • 10.1 to 20 lbs . . . 270 mg (orange box - one tablet)
    
  • 20.1 to 40 lbs . . . 560 mg (green box - one tablet)
    
  • 40.1 lbs to 60 lbs . . . 810 mg (blue box- one tablet)
    
  • 60.1 to 120 lbs . . . 1620 mg (brown box - one tablet)

Administer COMFORTIS chewable tablets with food for maximum effectiveness.

COMFORTIS is a chewable tablet and is readily consumed by dogs when offered by the owner just prior to feeding. Alternatively, COMFORTIS chewable tablets may be offered in food or administered like other tablet medications. COMFORTIS chewable tablets should be administered at monthly intervals.

If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed, administer COMFORTIS chewable tablets with food and resume a monthly dosing schedule.

Treatment with COMFORTIS chewable tablets may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with COMFORTIS chewable tablets should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.

Contraindications:

There are no known contraindications for the use of COMFORTIS chewable tablets.

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian

Warnings:

Not for human use. Keep this and all drugs out of the reach of children.

Precautions:

COMFORTIS chewable tablets are for use in cats, dogs, kittens and puppies 14 weeks of age and older

Adverse Reactions:
No serious adverse reactions were observed with COMFORTIS chewable tablets. All reactions are regarded as mild.

Mode of Action:

The primary target of action of COMFORTIS chewable tablets in insects is an activation of nicotinic acetylcholine receptors (nAChRs). Spinosad does not interact with known insecticidal binding sites of other nicotinic or GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins, and cyclodienes. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis, and flea death. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs.

How Supplied:

COMFORTIS chewable tablets are available in six flavored tablet sizes: 90, 140, 270, 560, 810 or 1620 mg. Each tablet size is available in color-coded packages of 6 tablets.

Elanco

Rx Medication Sold Only To Licensed Veterinarians & pharmacies. Current License Must Be On File Prior To Shipping.