Dog Parasites:

• Control and prevention of flea infestation (Ctenocephalides felis)
• Prevention of heartworm disease (Dirofilaria immitis)
• Treatment and control of ear mite infestation (Otodectes cynotis)
• Treatment and control of sarcoptic mange (Sarcoptes scabiei)
• Control of the American Dog Tick (Dermacentor variabilis)

Cat Parasites:

• Control and prevention of flea infestation (Ctenocephalides felis)
• Prevention of heartworm disease (Dirofilaria immitis)
• Treatment and control of ear mite infestation (Otodectes cynotis)
• Treatment and control of intestinal worms

Roundworm (Toxocara cati)
Hookworm (Ancylostoma tubaeforme)

Once applied, Revolution enters the bloodstream through the skin. Concentrations of Revolution in the blood and intestinal tract prevent heartworm disease and treat gastrointestinal parasites, respectively. Revolution selectively redistributes from blood to sebaceous glands, which are found below the skin's surface. Revolution's presence in the sebaceous glands and in the skin is the reservoir of drug that provides protection against fleas, flea eggs, ticks and mites.

Revolution should be used with caution in sick, debilitated or underweight animals.
Dogs should be tested for heartworm disease prior to giving Revolution. If your dog tests positive for adult heartworms, your veterinarian can recommend appropriate
treatment. Dogs infected with adult heartworms can safely be given Revolution.

Dosage for your Pet:
Your veterinarian will recommend the appropriate dose for your dog or cat based on your animal’s body weight. You should not administer Revolution to your dog or cat
if he/she is younger than 6 weeks of age. Revolution is available in six separate dose strengths for dogs and cats of different weights.

What should I do if I do not give Revolution on time or miss a dose?
If you forget to apply a monthly dose of Revolution, immediately apply Revolution, resume monthly applications, and notify your veterinarian.

What if I administer more than the prescribed amount of Revolution to my dog or cat?
Contact your veterinarian if you administer more than the prescribed amount of Revolution.

How should Revolution be applied?

Do not massage Revolution into the skin.

Do not apply when the hair coat is wet.

Do not apply to broken skin—Revolution contains alcohol.
Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the site in some animals. These effects are usually temporary and do not affect the safety or effectiveness of the product.

Can I give my pet a bath after applying Revolution?
Yes. Studies show that effectiveness is not reduced by bathing or immersing your pet in water two hours after application.

When can I play with my pet following treatment with Revolution?
You should avoid contact with application site when wet. You may hold or play with your pet any time after the area on which Revolution was applied is dry.

I see fleas on my dog or cat. Is Revolution working?
Revolution kills adult fleas and prevents flea eggs from hatching. You may occasionally see a few fleas on dogs or cats treated with Revolution but more than 98% of adult fleas are killed within 36 hours.

Immature stages of the flea called pupae may be present in your pets’ environment (yard, flooring, carpet, bedding, etc.). These pupae are not killed by parasiticides (including Revolution) and as such may emerge as adult fleas. These adult fleas may hop onto your pet at anytime. They must be exposed to Revolution on your dog or cat before being killed. It can take from 3–5 weeks (or longer depending on environmental conditions) for most fleas to complete their 4-stage life cycle (egg, larvae, pupae, and adult) and reach the adult stage before being seen on your pet. Due to the presence of immature flea stages in infested environments, it can take up to 2 to 3 monthly applications for Revolution to maximally control the infestation of fleas in the environment. Once the flea population is controlled you will be less likely to see fleas.

I see ticks on my dog. Is Revolution working?
Revolution controls tick infestations only due to the American Dog Tick (Dermacentor variabilis), a tick commonly found on dogs. There are other common species of ticks that are not killed or controlled by Revolution. Your veterinarian can recommend
appropriate products to control or kill ticks common to your area. For the control of
the American Dog Tick, Revolution should be applied once a month; however, your
veterinarian may recommend a second administration applied 14 days after the first dose if your dog has a heavy tick infestation and/or recommend additional tick control methods. It may take up to 5 days to kill the majority of ticks on your dog.

What are the possible side effects of Revolution?
Like all medicines, Revolution has some side effects. The most common is hair loss
at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing,
pruritus (itching), urticaria (welts, hives), and erythema (skin redness). Seizures and ataxia (incoordination) were observed rarely.

If you have additional questions about possible side effects, talk to your veterinarian.

Can Revolution be given with other medicines?
In well-controlled clinical studies, Revolution was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolution. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog’s or cat’s medicines can be given together.

How should Revolution be stored?
Revolution is flammable—Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.

What else should I know about Revolution?
Revolution is not for use in humans. Revolution should be kept out of reach of
children. In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. In case of human ingestion contact a doctor immediately.

Product Information Provided by Pfizer Animal Health.   © Pfizer Animal Health